Pair of fun, love camping trip is a great way to create that relationship. You can also travel to plan a trip around a special day.
Importance
Love the camping trip, two natural love, and spend time together watching a rural environment at the appropriate time. Playing horse, biking, fishing, when one spends more time to be able to offer additional activities. You spring and summer temperatures, when the facility is planned to be warm enough to camp was the best most romantic camping trip. We love the weather can not make the right adjustments and accommodation while on a camping trip, a trip can blossom. It will be less than usual, and with a tarpaulin cover, when more rain is expected, before going on a journey, to understand local weather.
Considerations
When planning a camping trip to find time, you must do so in advance of a few weeks, the first step should be. When selecting a site for a camp, you can be sure that your lover will have a lot of privacy ? you choose location where a semi-isolated away from the other camp. A trip on the two measures will soon understand that. This should ensure that you have the right swimsuit style bike ride, and equipment to create the item. The need to create a list, so do not forget anything.
Model
RV camp in the car on the use of a wide range of Camper trailer truck, motor home, or pop the car is traveling. The old camp, you can choose a tent or hut. Some campers and a sleeping bag or blanket to use concrete with raw nature. You have water, electricity and other equipment base AA and love a trip to camp, take, or wood lot to choose from, it will be like, you lack, such as fire, light Grill on cooking a tripod and a bright love to act, and battery-powered portable, to a flashlight.
Feature
Lakes and rivers for boating and water near the camp of Canoeing. This is good for the body to be active, a great way to share some time alone. Background on the nature of the integration, the Woods camp, background, love, nature. It provides a comfortable and romantic environment because, campfire, fire starter, please do so. You through water and lunch or a romantic dinner, you can eat in the camp or units. Table, wild flowers such as tea sets can create an atmosphere of natural products such as candles and bombs. A pleasant music in the background, you can create a natural sound. A relaxed and comfortable with ambiguity, coordination and feather pillow and blanket lavender ? the smell of feathers, we will create an oasis bedroom to make love. Bring your camera to take pictures of the test.
Impact
Camping trip memorable romantic camping trip is a collection of components that can operate smoothly, it would be useful to reduce the level of tension. The success of the camp experience is necessary for the packing of goods. The preparation of food is a food and travel arrangements, lightweight materials and plastic materials for packaging heavy and relaxed in an air-lock container. As long as the food?s not as perishable as it?s recorded. I cook the meat to prevent corruption, or the first day of camp, vegetables and fresh food stored in a cooler, can be. Security, and other materials in order to ensure, fire starter lighter and flammable, do this alone. Index card, or some quotes Shakespeare in love, create your own, you have to add on to act out of love. Romantic couple camping trip to enjoy the outdoors and spend some time with the car from everyday life and allows one beat ?em up.
Source: http://www.vitorbarrosdias.com/romantic-camping-trip.html
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Source: http://cituput.posterous.com/romantic-camping-trip-exclusive-travel-and-le
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Last time we checked in with the 3D printing upstarts over at Formlabs, their Kickstarter was doing splendidly, having over doubled its initial funding target. Well, less than a month later, and with the money still rolling in, the current total stands (at time of writing) at a somewhat impressive $2,182,031 -- over 20 times its initial goal. When we heard that the team behind it, along with some all important working printers, rolled into town, how could we resist taking the opportunity to catch up? The venue? London's 3D print show. Where, amongst all the printed bracelets and figurines, the FORM 1 stood out like a sore thumb. A wonderfully orange, and geometrically formed one at that. We elbowed our way through the permanent four-deep crowd at their booth to take a closer look, and as the show is running for another two days, you can too if you're in town. Or you could just click past the break for more.
Filed under: Misc
Formlabs FORM 1 high-resolution 3D printer spotted in the wild, we go eyes on (video) originally appeared on Engadget on Fri, 19 Oct 2012 15:00:00 EDT. Please see our terms for use of feeds.
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Formlabs (Kickstarter) | Email this | CommentsSource: http://www.engadget.com/2012/10/19/formlabs-form-1-eyes-on/
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You think I?m totally gross, right? I know, I get it. ?Wait, reusable WHAT?? is probably how your thought process went.
When I first heard the term ?family cloth,? it conjured up such a lovely image, like a warm snuggly blanket that?s big enough for the whole family. But no. It?s actually when you use cloth toilet paper, and then put it through the wash, and then use it again. Which is, you know ? different.
My initial reaction was the same as most people?s ? something along the lines of, ?Ew, gross!? But then my second thought was ? ?Well, wait. Maybe that kinda makes sense?? See, I was raised by hippies ? all burning sage and dancing drum circles in dry river beds and the like ? so I guess my psyche is primed for that outside-the-norm, super-green lifestyle sort of stuff. For those with a more conventional bent, please just bear with me a moment.
Much like forgoing traditional roofing for a living roof, the concept is alarming at first (our cultural conditioning does run deep), but really, it?s actually just a matter of common sense. We don?t wear disposable underwear, right? And we do accept cloth diapers for babies, and many of those cloth-diapering parents choose to use cloth wipes as well. Some people even use cloth menstrual pads. Each of these are sociopolitical decisions, which factor in issues like finances, environmental impact, and individual values.
For me, this one was an eco-conscious no-brainer ? once I?d wrapped my brain around the concept, that is. I mean, of course! Cloth can be washed and used again and again. It?s less resource-intensive, it keeps tons and tons of waste out of landfills and waterways, and, bottom line, the ?reusable? model is always a more sustainable choice than the ?disposable? alternative.
Just think about toilet paper: Made from trees. Chemically-treated for ?sanitation,? and bleached for ?beauty.? Stark white antiseptic. Wrapped in plastic. Mass-produced in factories. Shipped across continents. Endlessly.
Then think about family cloth. Homemade. Cut from an old cotton sheet, a flannel shirt, a terry cloth towel. All up-cycled. And so soft. Washable. Reusable. Again and again and again.
For me, my choice was pretty clear.
And with that, I was off. I cut up a stack of my husband?s old shirts, using pinking sheers so the edges wouldn?t fray. I displayed my cloth wipes neatly arranged, in a basket atop the back of the toilet. Some people choose to keep their cloth in a easy-to-reach drawer, or a covered container. It?s really just a matter of preference.
To be clear, I use my wipes for #1 only. This helps keep things cleaner and I don?t worry quite as much about germs. I drop my used wipes in a lidded plastic wastebasket next to the toilet. When it?s full, I take them downstairs to the wash, and clean them well.
Since I only use wipes for #1, I always have toilet paper available. It?s great for guests, and my husband. No one else ever has to deal with my wipes. Nobody, not even my Portland plumber, knows what?s going on.
In the end ? well, may I be blunt? I mean, the environment is awesome and all, but honestly? Cloth really just feels better. I?ll take warm soft cotton over scratchy paper any day. Maybe I?m just a born-and-bred hippie like that.
?
?
Related:
12 Disposable Items to Dispose of for Good
Regular vs. Recycled Toilet Paper
Bidet in a Bottle ? A Handheld Backside Cleanser
Source: http://www.care2.com/greenliving/would-you-use-reusable-toilet-paper.html
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Sinusitis: Leaving a bad taste in your mouth
The immune system protects the upper respiratory tract from bacterial infections, but the cues that alert the immune system to the presence of bacteria are not known. In this issue of the Journal of Clinical Investigation, researchers led by Noam Cohen at the University of Pennsylvania demonstrated that the bitter taste receptor T2R38 regulates the immune defense of the human upper airway. Cohen and colleagues found that T2R38 was expressed in the cells that line the upper respiratory tract and could be activated by molecules secreted by Pseudomonas aeruginosa and other bacteria. Additionally, they found that common polymorphisms in the T2R38 gene were correlated with the incidence of bacterial sinus infections. These results demonstrate that genetic variation contributes to individual differences in susceptibility to respiratory infection. In a companion piece, Alice Prince of Columbia University discusses the role of bitter taste receptors in immune defense.
TITLE:
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
AUTHOR CONTACT:
Noam Cohen
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Phone: 215-823-5800 ext 3892; Fax: 215-349-5977; E-mail: cohenn@uphs.upenn.edu
View this article at: http://www.jci.org/articles/view/64240?key=8713f7c1bd015e43f32d
ACCOMPANYING COMMENTARY
TITLE:
The bitter tast of infection
AUTHOR CONTACT:
Alice S. Prince
Columbia University, New York, NY, USA
Phone: 212/305-4193; Fax: 212-305-2284; E-mail: asp7@columbia.edu
View this article at: http://www.jci.org/articles/view/66182?key=3da926f3262c7c8e0664
Synaptic protein linked to Levodopa-induced dyskinesia
Dopamine replacement is a standard treatment for Parkinson's disease; however, one of the side effects is a movement disorder known as Levodopa-induced dyskinesia (LID). In a study published in the Journal of Clinical Investigation, Erwan Bezard and colleagues at the University of Bordeaux found that the protein PSD-95, which which organizes proteins at neuronal synapses, was overexpressed in monkeys with LID. PSD-95 determines the cellular localization of the D1 dopamine receptor (D1R) and excess PSD-95 altered dopamine signaling to induce LID symptoms . By disrupting the interaction between D1R and PSD-95, Bezard and colleauges were able to improve LID symptoms in rats and monkeys. Imaging studies revealed that loss of PSD-95 reduced the amount of D1R at the synapse. These studies suggest that PSD-95 may be a suitable therapeutic target to ameliorate a major side effect of Parkinson's disease treatment.
TITLE:
PSD-95 expression controls L-dopa dyskinesia through Dopamine D1 receptor trafficking
AUTHOR CONTACT:
Erwan Bezard
CNRS UMR 5543, Bordeaux, , FRA
Phone: +33557574762; Fax: +33556901421; E-mail: erwan.bezard@umr5543.u-bordeaux2.fr
View this article at: http://www.jci.org/articles/view/59426?key=12bc325376cad5452bf0
Researchers elucidate role of progranulin in frontotemporal dementia
Loss of one copy of the gene that codes for the protein progranulin (PGRN) is a major cause of frontotemporal dementia; however, the mechanism by which loss of PGRN causes neurodegeneration is unknown. In a study published in the Journal of Clinical Investigation, researchers led by Robert Farese at the University of California, San Francisco, demonstrated that loss of PGRN increased neuron loss in response to CNS injury in mice. PGRN was required to attenuate the post-injury inflammatory response that causes neuronal damage. These findings suggest that PGRN deficiency may contribute to increased neural inflammation and subsequent neurodegeneration.
TITLE:
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
AUTHOR CONTACT:
Robert Farese, Jr.
University of California, San Francisco, San Francisco, CA, USA
Phone: 415-734-2000; Fax: 415-355-0960; E-mail: bfarese@gladstone.ucsf.edu
View this article at: http://www.jci.org/articles/view/63113?key=20438e27a6b211302a62
Defining the pathogenesis of spinocerebellar ataxia
Spinocerebellar ataxia 28 (SCA28) is an inherited neuropathy characterized by a lack of muscle coordination affecting the limbs and the muscles that control the eyes. Mutations in the AFG3L2 gene have been linked to SCA28, but the pathogenic mechanism is undefined. In a study published in the Journal of Clinical Investigation, researchers led by Elena Rugarli at the University of Cologne found that AFG3L2 was required for the survival of Purkinje cells, which are involved in the coordination of movement. Using AFG3L2-mutant mice, Rugarli and colleagues demonstrated that Purkinje cells expressing mutant AFG3L2 had defects in mitochondrial protein synthesis that eventually killed the cells, leading to neurodegeneration and the movement disorder that characterizes SCA28.
TITLE:
AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival
AUTHOR CONTACT:
Elena Rugarli
Center for Molecular Medicine, University of Cologne, Kln, UNK, DEU
Phone: +49 221 470 8290 (office); Fax: + 49 221 470 8590; E-mail: elena.rugarli@uni-koeln.de
View this article at: http://www.jci.org/articles/view/64604?key=de37c55e6c7158264e15
Hedgehog signaling is associated with poor clinical outcome in intermediate risk prostate cancer
Prostate cancer patients are classified into low, intermediate, and high-risk groups that reflect relative survival categories. While there are accepted treatment regimens for low and high-risk patients, intermediate risk patients pose a clinical dilemma, as treatment outcomes are highly variable for these individuals. In this issue of the Journal of Clinical Investigation, Ruth Muschel and colleagues at the University of Oxford identified the protein PN1 as a negative regulator of the oncogenic Hedgehog signaling pathway in prostate cancer. In a mouse model of prostate cancer, increased expression of PN1 inhibited tumor growth. Further, comparisons of tumor tissue from human prostate cancer patients showed that genetic alterations in Hedgehog pathway regulators correlated with worse clinical outcomes in intermediate risk patients.
TITLE:
Protease Nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma
AUTHOR CONTACT:
Ruth Muschel
University of Oxford, Oxford, UNK, GBR
Phone: +44 1865 225847; Fax: +44 1865 857533; E-mail: ruth.muschel@gmail.com
View this article at: http://www.jci.org/articles/view/59348?key=f202b12d4c35856085af
MicroRNA-155 influences atherosclerotic plaque formation
Atherosclerosis causes the thickening and hardening of the arteries. Macrophages participate in the formation of atherosclerotic plaques by driving inflammatory responses, accumulating LDL, and releasing factors that influence the behavior of cells within the plaque. MicroRNAs (miRs) control the activity of macrophages by regulating gene expression, but the exact roles of different miRs remain undefined. In a study published in the Journal of Clinical Investigation, Andreas Schober and colleagues at Ludwig Maximilians University in Munich, Germany report that miR-155 is induced by LDL and inflammatory factors in macrophages. Expression of miR-155 in macrophages reduced atherosclerotic plaque formation in mice by repressing the transcription factor Bcl6, which attenuates inflammatory signaling pathways. This study demonstrates that miR-155 plays a key role in macrophage-mediated vascular inflammation in atherosclerosis.
TITLE:
MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages
AUTHOR CONTACT:
Andreas Schober
LMU Munich, Munich, , DEU
Phone: 49-89-51605151; E-mail: aschober@med.lmu.de
View this article at: http://www.jci.org/articles/view/61716?key=d4983c810db5e81a2a97
A new model of Shiga toxin-producing E. coli infection
Shiga toxin-producing E. coli (STEC) have been implicated in multiple outbreaks of food-borne illness and can cause intestinal and systemic disease, including severe renal damage. Upon attachment to the intestine, STEC generate lesions that allow the shiga toxin to cross the intestinal wall and enter the blood stream. Current mouse models of STEC do not accurately reflect this aspect of the human disease and the molecular mechanisms that allow the Shiga toxin to enter the blood stream are undefined. In a study published in the Journal of Clinical Investigation, John Leong and colleagues at Tufts University developed a mouse model of STEC infection that replicated the intestinal damage seen in the human disease. This new model will serve as a platform to determine how STEC crosses the intestinal wall to cause systemic disease.
TITLE:
A novel murine infection model for Shiga toxin-producing Escherichia coli
AUTHOR CONTACT:
John Leong
Tufts University School of Medicine, Boston, MA, USA
Phone: 617-636-0488; Fax: 617-636-0335; E-mail: John.Leong@tufts.edu
View this article at: http://www.jci.org/articles/view/62746?key=748f1dbd5c1c949d3eb4
Viral antigen cross-presentation protects dendritic cells from infection
Dendritic cells (DC) are gatekeepers that patrol the body, looking for signs of infection. Once they find a virus, they sample a bit of the virus and present the viral antigens to T cells, which are responsible for finding and killing infected cells. The role of DC antigen cross-presentation in the induction of anti-viral cytotoxic T cells is not entirely clear. In a study published in the Journal of Clinical Investigation, researchers led by Miriam Merad at Mount Sinai Medical School used a recombinant, fluorescent influenza virus to visualize antigen presentation of DC cells in the lungs of mice infected with influenza. They found that a specific subset of DC cells (CD103+) carried fluorescent virus to the lymph nodes, where they induced virus-specific T cells. Additionally, cross-presenting DCs were protected from viral infection.
TITLE:
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection
AUTHOR CONTACT:
Miriam Merad
Mount Sinai School of Medicine, New York, NY, USA
Phone: (212) 659-8276; Fax: ; E-mail: miriam.merad@mssm.edu
View this article at: http://www.jci.org/articles/view/60659?key=75c26e6afdda1d2ec0bb
Endotrophin links obesity to breast cancer progression
Fat cells (adipocytes) surround breast tumors and contribute to tumor growth by expressing factors that aid oncogenesis. Col6 is a protein that is highly expressed in adipocytes and its expression is further increased in both obesity and in breast cancer cells. In this issue of the Journal of Clinical Investigation, Phillip Scherer and Jiyoung Park of the University of Texas Southwestern Medical Center report that a portion of the Col6 protein, known as endotrophin, alters the tumor environment to promote tumor growth and metastasis in mice. Mice with reduced endotrophin expression had significantly less tumor burden and fewer metastases. These findings link obesity and cancer progression and suggest that endotrophin may serve as novel therapeutic target in the treatment of breast cancer.
TITLE:
Endotrophin links obesity to breast cancer progression
AUTHOR CONTACT:
Philipp E. Scherer
The University of Texas Southwestern Medical Center, Dallas, TX, USA
Phone: (214) 648-8715; Fax: (214) 648-8720; E-mail: philipp.scherer@utsouthwestern.edu
View this article at: http://www.jci.org/articles/view/63930?key=9c997068a1667266d6f6
###
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Sinusitis: Leaving a bad taste in your mouth
The immune system protects the upper respiratory tract from bacterial infections, but the cues that alert the immune system to the presence of bacteria are not known. In this issue of the Journal of Clinical Investigation, researchers led by Noam Cohen at the University of Pennsylvania demonstrated that the bitter taste receptor T2R38 regulates the immune defense of the human upper airway. Cohen and colleagues found that T2R38 was expressed in the cells that line the upper respiratory tract and could be activated by molecules secreted by Pseudomonas aeruginosa and other bacteria. Additionally, they found that common polymorphisms in the T2R38 gene were correlated with the incidence of bacterial sinus infections. These results demonstrate that genetic variation contributes to individual differences in susceptibility to respiratory infection. In a companion piece, Alice Prince of Columbia University discusses the role of bitter taste receptors in immune defense.
TITLE:
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
AUTHOR CONTACT:
Noam Cohen
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Phone: 215-823-5800 ext 3892; Fax: 215-349-5977; E-mail: cohenn@uphs.upenn.edu
View this article at: http://www.jci.org/articles/view/64240?key=8713f7c1bd015e43f32d
ACCOMPANYING COMMENTARY
TITLE:
The bitter tast of infection
AUTHOR CONTACT:
Alice S. Prince
Columbia University, New York, NY, USA
Phone: 212/305-4193; Fax: 212-305-2284; E-mail: asp7@columbia.edu
View this article at: http://www.jci.org/articles/view/66182?key=3da926f3262c7c8e0664
Synaptic protein linked to Levodopa-induced dyskinesia
Dopamine replacement is a standard treatment for Parkinson's disease; however, one of the side effects is a movement disorder known as Levodopa-induced dyskinesia (LID). In a study published in the Journal of Clinical Investigation, Erwan Bezard and colleagues at the University of Bordeaux found that the protein PSD-95, which which organizes proteins at neuronal synapses, was overexpressed in monkeys with LID. PSD-95 determines the cellular localization of the D1 dopamine receptor (D1R) and excess PSD-95 altered dopamine signaling to induce LID symptoms . By disrupting the interaction between D1R and PSD-95, Bezard and colleauges were able to improve LID symptoms in rats and monkeys. Imaging studies revealed that loss of PSD-95 reduced the amount of D1R at the synapse. These studies suggest that PSD-95 may be a suitable therapeutic target to ameliorate a major side effect of Parkinson's disease treatment.
TITLE:
PSD-95 expression controls L-dopa dyskinesia through Dopamine D1 receptor trafficking
AUTHOR CONTACT:
Erwan Bezard
CNRS UMR 5543, Bordeaux, , FRA
Phone: +33557574762; Fax: +33556901421; E-mail: erwan.bezard@umr5543.u-bordeaux2.fr
View this article at: http://www.jci.org/articles/view/59426?key=12bc325376cad5452bf0
Researchers elucidate role of progranulin in frontotemporal dementia
Loss of one copy of the gene that codes for the protein progranulin (PGRN) is a major cause of frontotemporal dementia; however, the mechanism by which loss of PGRN causes neurodegeneration is unknown. In a study published in the Journal of Clinical Investigation, researchers led by Robert Farese at the University of California, San Francisco, demonstrated that loss of PGRN increased neuron loss in response to CNS injury in mice. PGRN was required to attenuate the post-injury inflammatory response that causes neuronal damage. These findings suggest that PGRN deficiency may contribute to increased neural inflammation and subsequent neurodegeneration.
TITLE:
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
AUTHOR CONTACT:
Robert Farese, Jr.
University of California, San Francisco, San Francisco, CA, USA
Phone: 415-734-2000; Fax: 415-355-0960; E-mail: bfarese@gladstone.ucsf.edu
View this article at: http://www.jci.org/articles/view/63113?key=20438e27a6b211302a62
Defining the pathogenesis of spinocerebellar ataxia
Spinocerebellar ataxia 28 (SCA28) is an inherited neuropathy characterized by a lack of muscle coordination affecting the limbs and the muscles that control the eyes. Mutations in the AFG3L2 gene have been linked to SCA28, but the pathogenic mechanism is undefined. In a study published in the Journal of Clinical Investigation, researchers led by Elena Rugarli at the University of Cologne found that AFG3L2 was required for the survival of Purkinje cells, which are involved in the coordination of movement. Using AFG3L2-mutant mice, Rugarli and colleagues demonstrated that Purkinje cells expressing mutant AFG3L2 had defects in mitochondrial protein synthesis that eventually killed the cells, leading to neurodegeneration and the movement disorder that characterizes SCA28.
TITLE:
AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival
AUTHOR CONTACT:
Elena Rugarli
Center for Molecular Medicine, University of Cologne, Kln, UNK, DEU
Phone: +49 221 470 8290 (office); Fax: + 49 221 470 8590; E-mail: elena.rugarli@uni-koeln.de
View this article at: http://www.jci.org/articles/view/64604?key=de37c55e6c7158264e15
Hedgehog signaling is associated with poor clinical outcome in intermediate risk prostate cancer
Prostate cancer patients are classified into low, intermediate, and high-risk groups that reflect relative survival categories. While there are accepted treatment regimens for low and high-risk patients, intermediate risk patients pose a clinical dilemma, as treatment outcomes are highly variable for these individuals. In this issue of the Journal of Clinical Investigation, Ruth Muschel and colleagues at the University of Oxford identified the protein PN1 as a negative regulator of the oncogenic Hedgehog signaling pathway in prostate cancer. In a mouse model of prostate cancer, increased expression of PN1 inhibited tumor growth. Further, comparisons of tumor tissue from human prostate cancer patients showed that genetic alterations in Hedgehog pathway regulators correlated with worse clinical outcomes in intermediate risk patients.
TITLE:
Protease Nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma
AUTHOR CONTACT:
Ruth Muschel
University of Oxford, Oxford, UNK, GBR
Phone: +44 1865 225847; Fax: +44 1865 857533; E-mail: ruth.muschel@gmail.com
View this article at: http://www.jci.org/articles/view/59348?key=f202b12d4c35856085af
MicroRNA-155 influences atherosclerotic plaque formation
Atherosclerosis causes the thickening and hardening of the arteries. Macrophages participate in the formation of atherosclerotic plaques by driving inflammatory responses, accumulating LDL, and releasing factors that influence the behavior of cells within the plaque. MicroRNAs (miRs) control the activity of macrophages by regulating gene expression, but the exact roles of different miRs remain undefined. In a study published in the Journal of Clinical Investigation, Andreas Schober and colleagues at Ludwig Maximilians University in Munich, Germany report that miR-155 is induced by LDL and inflammatory factors in macrophages. Expression of miR-155 in macrophages reduced atherosclerotic plaque formation in mice by repressing the transcription factor Bcl6, which attenuates inflammatory signaling pathways. This study demonstrates that miR-155 plays a key role in macrophage-mediated vascular inflammation in atherosclerosis.
TITLE:
MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages
AUTHOR CONTACT:
Andreas Schober
LMU Munich, Munich, , DEU
Phone: 49-89-51605151; E-mail: aschober@med.lmu.de
View this article at: http://www.jci.org/articles/view/61716?key=d4983c810db5e81a2a97
A new model of Shiga toxin-producing E. coli infection
Shiga toxin-producing E. coli (STEC) have been implicated in multiple outbreaks of food-borne illness and can cause intestinal and systemic disease, including severe renal damage. Upon attachment to the intestine, STEC generate lesions that allow the shiga toxin to cross the intestinal wall and enter the blood stream. Current mouse models of STEC do not accurately reflect this aspect of the human disease and the molecular mechanisms that allow the Shiga toxin to enter the blood stream are undefined. In a study published in the Journal of Clinical Investigation, John Leong and colleagues at Tufts University developed a mouse model of STEC infection that replicated the intestinal damage seen in the human disease. This new model will serve as a platform to determine how STEC crosses the intestinal wall to cause systemic disease.
TITLE:
A novel murine infection model for Shiga toxin-producing Escherichia coli
AUTHOR CONTACT:
John Leong
Tufts University School of Medicine, Boston, MA, USA
Phone: 617-636-0488; Fax: 617-636-0335; E-mail: John.Leong@tufts.edu
View this article at: http://www.jci.org/articles/view/62746?key=748f1dbd5c1c949d3eb4
Viral antigen cross-presentation protects dendritic cells from infection
Dendritic cells (DC) are gatekeepers that patrol the body, looking for signs of infection. Once they find a virus, they sample a bit of the virus and present the viral antigens to T cells, which are responsible for finding and killing infected cells. The role of DC antigen cross-presentation in the induction of anti-viral cytotoxic T cells is not entirely clear. In a study published in the Journal of Clinical Investigation, researchers led by Miriam Merad at Mount Sinai Medical School used a recombinant, fluorescent influenza virus to visualize antigen presentation of DC cells in the lungs of mice infected with influenza. They found that a specific subset of DC cells (CD103+) carried fluorescent virus to the lymph nodes, where they induced virus-specific T cells. Additionally, cross-presenting DCs were protected from viral infection.
TITLE:
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection
AUTHOR CONTACT:
Miriam Merad
Mount Sinai School of Medicine, New York, NY, USA
Phone: (212) 659-8276; Fax: ; E-mail: miriam.merad@mssm.edu
View this article at: http://www.jci.org/articles/view/60659?key=75c26e6afdda1d2ec0bb
Endotrophin links obesity to breast cancer progression
Fat cells (adipocytes) surround breast tumors and contribute to tumor growth by expressing factors that aid oncogenesis. Col6 is a protein that is highly expressed in adipocytes and its expression is further increased in both obesity and in breast cancer cells. In this issue of the Journal of Clinical Investigation, Phillip Scherer and Jiyoung Park of the University of Texas Southwestern Medical Center report that a portion of the Col6 protein, known as endotrophin, alters the tumor environment to promote tumor growth and metastasis in mice. Mice with reduced endotrophin expression had significantly less tumor burden and fewer metastases. These findings link obesity and cancer progression and suggest that endotrophin may serve as novel therapeutic target in the treatment of breast cancer.
TITLE:
Endotrophin links obesity to breast cancer progression
AUTHOR CONTACT:
Philipp E. Scherer
The University of Texas Southwestern Medical Center, Dallas, TX, USA
Phone: (214) 648-8715; Fax: (214) 648-8720; E-mail: philipp.scherer@utsouthwestern.edu
View this article at: http://www.jci.org/articles/view/63930?key=9c997068a1667266d6f6
###
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-10/joci-jet100312.php
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MOSCOW?? A teenage mammoth that once roamed the Siberian tundra in search of fodder and females might have been killed by an Ice Age man on a summer day tens of thousands of years ago, a Russian scientist said Friday.
Professor Alexei Tikhonov of the Zoology Institute in St. Petersburg announced the discovery of the mammoth, which was excavated from the Siberian permafrost in late September near the Sopochnaya Karga cape, 3,500 kilometers (2,200 miles) northeast of Moscow.
The 16-year-old mammoth has been named Jenya, after the 11-year-old Russian boy who found the animal's limbs sticking out of the frozen mud. The mammoth was 2 meters (6 feet 6 inches) tall and weighed 500 kilograms (1,100 pounds).
"He was pretty small for his age," Tikhonov told The Associated Press.
What killed Jenya was not his size but a missing left tusk that made him unfit for fights with other mammoths or human hunters who were settling the Siberian marshes and swamps 20,000 to 30,000 years ago, Tikhonov said.
The splits on Jenya's remaining tusk show a "possible human touch," he added.
The examination of Jenya's body has already proved that the massive humps on mammoths seen on Ice Age cave paintings in Spain and France were not extended bones but huge chunks of fat that helped them regulate their body temperatures and survive the long, cold winters, Tikhonov said.
Jenya's hump was relatively big, which means that he died during a short Arctic summer, he said.
Up to 4 meters (13 feet) in height and 10 tons in weight, mammoths migrated across huge areas between Great Britain and North America and were driven to extinction by humans and the changing climate.
Wooly mammoths are thought to have died out around 10,000 years ago, although scientists think small groups of them lived longer in Alaska and on Russia's Wrangel Island off the Siberian coast.
Their bodies have mostly been found in the Siberian permafrost. Siberian cultural myths paint them as primordial creatures who moved underground and helped to create the Earth.
Most of the well-preserved mammoths are calves. Jenya's carcass is the best-preserved one since the 1901 discovery of a giant mammoth near the Beryozovka river in Russia's northeastern Yakutia region, Tikhonov said.
Unfortunately, its DNA has been damaged by low temperatures and is "hardly" suitable for possible cloning, he said.
However, an earlier mammoth discovery might be able to help re-create the Ice Age elephant.
Russia's North-Eastern Federal University said in early September that an international team of researchers had discovered mammoth hair, soft tissues and bone marrow 328 feet (100 meters) underground during a summer expedition in Yakutia.
Scientists already have deciphered much of the genetic code of the woolly mammoth from balls of mammoth hair found frozen in the Siberian permafrost. Some believe it's possible to re-create the prehistoric animal if they find living cells in the permafrost.
Those who succeed in re-creating an extinct animal could claim a "Jurassic Park prize," a concept being developed by the X Prize Foundation that awarded a 2004 prize for the first private spacecraft.
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Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Source: http://www.msnbc.msn.com/id/49304338/ns/technology_and_science-science/
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With so many options for importing your digital photos into your PC?including the one built into the operating system?why would you pay for a separate app for the job? If you do a Web search for "photo import software," Smart Photo Import always shows up at or near the top, and even more than once for download sites that offer it. So I thought I'd take it for a spin. Nothing in the experience really answered the above question in a convincing way.
Smart Import's site claims that it's not just intended for getting new photos from your camera media: It's also about organizing photo files already scattered around your hard drive. And beyond just photos from cameras, it can also use WIA (Windows Image Acquisition) to acquire images from scanners.
Setup/Signup
Smart Photo Import costs 13 euros, or about $18 USD, but you can download and install it as a full-featured free trial. And there's no time limit; paying for the registration just gets you priority support and more comprehensive documentation.
Interface
The app's interface has a shiny chrome-like look that was fashionable among program skins several years ago. You can change the design from the Skin menu to two different choices, though they don't change the look of the buttons. A standard menu bar across the top offers File, View, Action, Tools, Skin, and Help choices. Below are two tab options for PC Drive and WIA (for scanner input).
Functionality
As you'd expect, Smart Photo Import adds an entry to the AutoPlay option that pops up when you insert camera media into a USB slot. Clicking this button populates the app's main window with thumbnails of the photos. You have quite a few options for how these thumbnails are displayed, dropdowns offer captioning by filename, date, size, title, author, and comments. A vertical slider lets you enlarge the thumbnails.
Double clicking on a thumbnail opens the full image. The program had no problem importing native raw image files from my Canon T1i , and it also supports the T2i, but the T3i and T4i aren't yet on its compatibility list. Adobe Camera Raw (used by Lightroom and Photoshop ) already supports those newer models. Also, loading full raw images was a bit slow. But Windows doesn't offer the raw import on its own, and the Adobe products cost considerably more.
When viewing images for import, you can sort by name, date, file size, or type. You can also filter the view to just files of certain types?raw, video, or a custom date range. You can rotate individual or all photos before importing them. You can also choose to have the photos renamed using a description and counter.
But there's quite a lot that you can't do, and that includes things you can do with Windows' included photo importer. You can't rate the photos or apply keyword tags to them. And the pro tools like Lightroom actually let you perform preset photo adjustments before import. And I didn't see any option to ignore duplicates during importing.
To actually import the photos to your PC, you click the COPY button, which can be switched to MOVE, if you don't want to keep the photos on the original media source. A dialog pops up telling you how many files you'll copy and to where, and you then can add a Subject for the folder name and hit CONFIRM.
To test, I tried copying 170 raw files of about 20MB each. During the import, I saw a series of progress bars, with no information as to what the current activity or file being imported was. At one point, I hit Esc to cancel, and to my surprise, there was no confirmation asking whether I really wanted to cancel, just an Aborted message box. Smart Photo Import took about the same amount of time as Windows picture import and Lightroom to import the 170 images?6:30 minutes. Smart Photo Import creates a folder structure under Documents (not Photos) in the format MyPhotos/2012/06/17/project name. Frankly, the free Windows photo importer does just as good a job of organizing created folders by date as Lightroom does.
Scanning with Smart Photo Import is no more intuitive and helpful than importing photos. It was able to turn on my scanner, but it really offered nothing over Windows Fax and Scan, which is actually clearer to use.
The Smartest Way to Import Photos?
Smart Photo Import is a program that probably has outlived its usefulness. Windows' built-in Import pictures and videos feature actually does at least as good a job, and if you're serious about digital photography, you'll get better import features from an app like Adobe Photoshop Lightroom, which offers even more import options and supports more raw camera file formats. But even free options like Picasa or Windows Photo Gallery offer more in the way of organizing your photos. Smart Photo Import does do everything it claims, and doesn't crash; I just can't recommend it when there are better, free options.
More Photo Editing Reviews:
??? Smart Photo Import
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?? more
Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/GmUvgA-T7zI/0,2817,2410379,00.asp
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FILE -- In this photo taken Wednesday, May, 23, 2012, Pope Benedict XVI, flanked by his private secretary Georg Gaenswein, top left, and his butler Paolo Gabiele arrives at St.Peter's square at the Vatican for a general audience. Paolo Gabriele took the stand Tuesday, Oct. 2, 2012, in a Vatican courtroom to defend himself against a charge of aggravated theft. He said he is innocent of charges of stealing the pope's private correspondence but acknowledged he feels guilty of betraying the trust of the pontiff, whom he said he loved like a father. In other testimony Tuesday, the pope's private secretary, Monsignor Georg Gaenswein, testified that he began having suspicions about Gabriele after he realized three documents that appeared in the journalist's book could only have come from the office he shared with Gabriele. (AP Photo/Andrew Medichini)
FILE -- In this photo taken Wednesday, May, 23, 2012, Pope Benedict XVI, flanked by his private secretary Georg Gaenswein, top left, and his butler Paolo Gabiele arrives at St.Peter's square at the Vatican for a general audience. Paolo Gabriele took the stand Tuesday, Oct. 2, 2012, in a Vatican courtroom to defend himself against a charge of aggravated theft. He said he is innocent of charges of stealing the pope's private correspondence but acknowledged he feels guilty of betraying the trust of the pontiff, whom he said he loved like a father. In other testimony Tuesday, the pope's private secretary, Monsignor Georg Gaenswein, testified that he began having suspicions about Gabriele after he realized three documents that appeared in the journalist's book could only have come from the office he shared with Gabriele. (AP Photo/Andrew Medichini)
FILE- In this Monday, April 21, 2008 file photo, Pope Benedict XVI's butler Paolo Gabriele, right, carries the pontiff's bags as they arrive at Ciampino military airport in Rome from a six-day trip in the U.S. Pope Benedict XVI's ex-butler Paolo Gabriele and another Vatican lay employee, Claudio Sciarpelletti, are scheduled to go on trial Saturday, Sept. 29, 2012, in the embarrassing theft of papal documents that exposed alleged corruption at the Holy See's highest levels. Gabriele was arrested May 24 after Vatican police found what prosecutors called an "enormous'' stash of documents from the pope's desk in his Vatican City apartment. (AP Photo/Domenico Stinellis, File)
RETRANSMISSION TO PROVIDE ALTERNATIVE CROP - In this photo released by the Vatican paper L'Osservatore Romano, pope's butler Paolo Gabriele sits in the wood-trimmed courtroom of the Vatican tribunal, at the Vatican, Saturday, Sept. 29, 2012. The Vatican opened the public trial Saturday of the pope's butler for allegedly stealing and leaking papal correspondence to a journalist, the most embarrassing scandal of Pope Benedict XVI's papacy. Paolo Gabriele, a 46-year-old father of three, faces up to four years in prison if he is convicted of aggravated theft in the worst security breach in the Vatican's recent history. He has already confessed, saying he acted to shed light on what he called "evil and corruption" in the church, and asked to be pardoned by the pope, something Vatican watchers say is a given if he is convicted. (AP Photo/L'Osservatore Romano)
In this photo released by the Vatican paper L'Osservatore Romano, pope's butler Paolo Gabriele, right, sits in the wood-trimmed courtroom of the Vatican tribunal, at the Vatican, Saturday, Sept. 29, 2012. The Vatican opened the public trial Saturday of the pope's butler for allegedly stealing and leaking papal correspondence to a journalist, the most embarrassing scandal of Pope Benedict XVI's papacy. Paolo Gabriele, a 46-year-old father of three, faces up to four years in prison if he is convicted of aggravated theft in the worst security breach in the Vatican's recent history. He has already confessed, saying he acted to shed light on what he called "evil and corruption" in the church, and asked to be pardoned by the pope, something Vatican watchers say is a given if he is convicted. (AP Photo/L'Osservatore Romano)
RETRANSMISSION TO PROVIDE ALTERNATIVE CROP - In this photo released by the Vatican paper L'Osservatore Romano, pope's butler Paolo Gabriele, right, sits in the wood-trimmed courtroom of the Vatican tribunal, at the Vatican, Saturday, Sept. 29, 2012. The Vatican opened the public trial Saturday of the pope's butler for allegedly stealing and leaking papal correspondence to a journalist, the most embarrassing scandal of Pope Benedict XVI's papacy. Paolo Gabriele, a 46-year-old father of three, faces up to four years in prison if he is convicted of aggravated theft in the worst security breach in the Vatican's recent history. He has already confessed, saying he acted to shed light on what he called "evil and corruption" in the church, and asked to be pardoned by the pope, something Vatican watchers say is a given if he is convicted. (AP Photo/L'Osservatore Romano)
VATICAN CITY (AP) ? Pope Benedict XVI's onetime butler declared Tuesday he was innocent of a charge of aggravated theft of the pope's private correspondence, but acknowledged he photocopied the papers and said he feels guilty that he betrayed the trust of the pontiff he loves like a father.
Paolo Gabriele took the stand Tuesday in a Vatican courtroom to defend himself against accusations of his role in one of the most damaging scandals of Benedict's pontificate. Prosecutors say Gabriele stole the pope's letters and documents alleging power struggles and corruption inside the Vatican and leaked them to a journalist in an unprecedented papal security breach.
Gabriele faces four years in prison if he is found guilty, although most Vatican watchers expect he will receive a papal pardon if he is convicted.
During Tuesday's hearing, Gabriele's attorney complained that her client spent his first 20 days in Vatican detention in a room so small he couldn't stretch his arms out and with lights kept on 24 hours a day. Vatican police swiftly defended their treatment of Gabriele, but the Vatican prosecutor opened an investigation regardless.
Prosecutors have said Gabriele, 46, has confessed to leaking copies of the documents to Italian journalist Gianluigi Nuzzi, because he wanted to expose the "evil and corruption" in the church. They quoted him as saying in a June 5 interrogation that even though he knew taking the documents was wrong, he felt inspired by the Holy Spirit "to bring the church back on the right track."
Judge Giuseppe Dalla Torre asked Gabriele on Tuesday if he stood by his confession. Gabriele responded: "Yes."
Asked, though, by his attorney Cristiana Arru how he responded to the charge of aggravated theft, Gabriele said: "I declare myself innocent concerning the charge of aggravated theft. I feel guilty of having betrayed the trust of the Holy Father, whom I love as a son would."
He insisted he had no accomplices, though he acknowledged that many people inside the Vatican, including cardinals, trusted him and would come to him with their problems and concerns. He said he felt inspired by his faith to always give them a listen.
He acknowledged he photocopied papal documentation, but insisted he did so in plain view of others and during daylight office hours, using the photocopier in the office he shared with the pope's two private secretaries.
The trial opened over the weekend inside the intimate ground-floor tribunal in the Vatican's courthouse tucked behind St. Peter's Basilica. Dalla Torre has said he expects it to be over within three more hearings.
In addition to Gabriele, the court heard Tuesday from four witnesses, including the pope's main private secretary, Monsignor Georg Gaenswein, who along with Gabriele was the closest assistant to the pontiff.
Gaenswein testified that he began having suspicions about Gabriele after he realized three documents that appeared in Nuzzi's book could only have come from their shared office.
"This was the moment when I started to have my doubts," Gaenswein said.
The book, "His Holiness: Pope Benedict XVI's private papers," became an immediate blockbuster when it was published May 20, detailing intrigue and scandals inside the Apostolic Palace. The leaked documents seemed primarily aimed at discrediting Benedict's No. 2, Cardinal Tarcisio Bertone, often criticized for perceived shortcomings in running the Vatican administration.
Gaenswein said as soon as he read the book, he immediately asked the pope's permission to convene a meeting of the small papal family to ask each member if he or she had taken the documentation.
One member, Cristina Cernetti, one of the pope's four housekeepers, told the court she knew immediately that Gabriele was to blame because she could exclude without a doubt any other member of the family.
In an indication of the respect Gabriele still feels for Gaenswein, he stood up from his bench when Gaenswein entered the courtroom and then again when he exited. Gaenswein seemed to not acknowledge him.
The trial resumes Wednesday with the testimony of four members of the Vatican police force who conducted the search of Gabriele's Vatican City apartment on May 23. In testimony Tuesday, two police officers said they discovered thousands of papers in Gabriele's studio, some of them originals.
During the testimony, the lawyer Arru complained about the conditions under which Gabriele spent his first 20 days in detention ? conditions which Gabriele said contributed to his "psychological depression."
Dalla Torre asked the prosecutor to open an investigation, which he did.
Vatican spokesman the Rev. Federico Lombardi said the size of the cell conformed to international standards and that, anyway, Gabriele was moved to a bigger cell after it was renovated.
The Vatican police responded quickly with a lengthy statement insisting that Gabriele's rights had been respected, citing the meals, free time, socializing, spiritual assistance and health care that Gabriele enjoyed during his nearly two months of detention. They said the lights were kept on for security reasons and to ensure Gabriele didn't harm himself, and that he had a mask he could use to block out the light.
The police warned that they may file a counter complaint against Arru if the investigation shows no wrongdoing on their part.
The trial is being conducted according to the Vatican's criminal code, which is adapted from the 19th-century Italian code. As is the case in Italian trials, the court reporter doesn't take down verbatim quotes, but rather records reconstructed summaries dictated to her by the court president, Dalla Torre.
___
Follow Nicole Winfield at www.twitter.com/nwinfield
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